Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma

Authors: Madi Y. Cissé, Samuel Pyrdziak, Nelly Firmin, Laurie Gayte, Maud Heuillet, Floriant Bellvert, Maryse Fuentes, Hélène Delpech, Romain Riscal, Giuseppe Arena, Frédéric Chibon, Sophie Le Gellec, Aurélie Maran-Gonzalez, Marie-Christine Chateau, Charles Theillet, Sébastien Carrere, Jean-Charles Portais, Laurent Le Cam, Laetitia K. Linares

Published: 2020-06-10

DOI: 10.1126/scitranslmed.aay2163

Source: Full article

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Abstract

Chromatin-bound MDM2 regulates serine metabolism and nucleotide synthesis to sustain tumor growth in liposarcoma.