Down-regulation of Beclin1 promotes direct cardiac reprogramming

Authors: Li Wang, Hong Ma, Peisen Huang, Yifang Xie, David Near, Haofei Wang, Jun Xu, Yuchen Yang, Yangxi Xu, Tiffany Garbutt, Yang Zhou, Ziqing Liu, Chaoying Yin, Michael Bressan, Joan M. Taylor, Jiandong Liu, Li Qian

Published: 2020-10-21

DOI: 10.1126/scitranslmed.aay7856

Source: Full article

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Abstract

Beclin1 suppresses induced cardiomyocyte reprogramming through an autophagy-independent, Wnt signaling–dependent pathway.