iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy

Authors: Frank Cichocki, Ryan Bjordahl, Svetlana Gaidarova, Sajid Mahmood, Ramzey Abujarour, Hongbo Wang, Katie Tuininga, Martin Felices, Zachary B. Davis, Laura Bendzick, Raedun Clarke, Laurel Stokely, Paul Rogers, Moyar Ge, Megan Robinson, Betsy Rezner, David L. Robbins, Tom T. Lee, Dan S. Kaufman, Bruce R. Blazar, Bahram Valamehr, Jeffrey S. Miller

Published: 2020-11-05

DOI: 10.1126/scitranslmed.aaz5618

Source: Full article

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Abstract

Natural killer cells derived from iPSCs prime T cells for anti–PD-1 immune checkpoint therapy.