Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy

Authors: Xueguang Lu, Lei Miao, Wenting Gao, Ziqi Chen, Kevin J. McHugh, Yehui Sun, Zachary Tochka, Stephanie Tomasic, Kaitlyn Sadtler, Alain Hyacinthe, Yuxuan Huang, Tyler Graf, Quanyin Hu, Morteza Sarmadi, Robert Langer, Daniel G. Anderson, Ana Jaklenec

Published: 2020-08-12

DOI: 10.1126/scitranslmed.aaz6606

Source: Full article

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Abstract

Microfabricated particles mimic multiple intratumoral injections of STING agonist over weeks to improve ease of use and decrease metastasis.