SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Authors: Magdalene K. Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B. Schittenhelm, Andrew Ryan, Scott L. Townley, Luke A. Selth, Trevor J. Biden, Gregory R. Steinberg, Dorit Samocha-Bonet, Ruth C. R. Meex, Matthew J. Watt

Published: 2020-09-02

DOI: 10.1126/scitranslmed.aaz8048

Source: Full article


Abstract

SMOC1 is a liver-secreted glucose-responsive protein that improves glycemic control through CREB-mediated suppression of hepatic glucose output.