Rituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia

Authors: Etienne Crickx, Pascal Chappert, Aurélien Sokal, Sandra Weller, Imane Azzaoui, Alexis Vandenberghe, Guillaume Bonnard, Geoffrey Rossi, Tatiana Fadeev, Sébastien Storck, Jehane Fadlallah, Véronique Meignin, Etienne Rivière, Sylvain Audia, Bertrand Godeau, Marc Michel, Jean-Claude Weill, Claude-Agnès Reynaud, Matthieu Mahévas

Published: 2021-04-14

DOI: 10.1126/scitranslmed.abc3961

Source: Full article

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Abstract

Rituximab-resistant memory B cells and newly engaged naive B cells join to fuel subsequent autoimmune responses in patients with relapsing ITP.