RETRACTED: A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells

Authors: Joydeep Mukherjee, Ajay Pandita, Chatla Kamalakar, Tor-Christian Johannessen, Shigeo Ohba, Yongjian Tang, Cecilia L. Dalle-Ore, Rolf Bjerkvig, Russell O. Pieper

Published: 2021-05-05

DOI: 10.1126/scitranslmed.abc7211

Source: Full article

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Abstract

Tumor cells using the ALT mechanism to maintain telomeres are uniquely sensitive to PARP inhibitor–induced lethal chromosomal fusion.