Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear

Authors: Josh Sun, Satoshi Uchiyama, Joshua Olson, Yosuke Morodomi, Ingrid Cornax, Nao Ando, Yohei Kohno, May M. T. Kyaw, Bernice Aguilar, Nina M. Haste, Sachiko Kanaji, Taisuke Kanaji, Warren E. Rose, George Sakoulas, Jamey D. Marth, Victor Nizet

Published: 2021-03-24

DOI: 10.1126/scitranslmed.abd6737

Source: Full article

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Abstract

The clinically approved drugs ticagrelor and oseltamivir fortify a pathway of platelet-mediated immunity to clear staphylococcal bacteremia in mice.