Authors: Jennifer A. Lo, Masayoshi Kawakubo, Vikram R. Juneja, Mack Y. Su, Tal H. Erlich, Martin W. LaFleur, Lajos V. Kemeny, Mamunur Rashid, Mohsen Malehmir, S. Alireza Rabi, Rumya Raghavan, Jennifer Allouche, Gyulnara Kasumova, Dennie T. Frederick, Kristen E. Pauken, Qing Yu Weng, Marcelo Pereira da Silva, Yu Xu, Anita A. J. van der Sande, Whitney Silkworth, Elisabeth Roider, Edward P. Browne, David J. Lieb, Belinda Wang, Levi A. Garraway, Catherine J. Wu, Keith T. Flaherty, Constance E. Brinckerhoff, David W. Mullins, David J. Adams, Nir Hacohen, Mai P. Hoang, Genevieve M. Boland, Gordon J. Freeman, Arlene H. Sharpe, Dieter Manstein, David E. Fisher
Published: 2021-02-17
DOI: 10.1126/scitranslmed.abd8636
Source: Full article
Neoantigens sensitize melanomas to checkpoint blockade and trigger epitope spreading to self-antigens, a process mimicked by combination immunotherapy.