Prosaposin mediates inflammation in atherosclerosis

Authors: Mandy M. T. van Leent, Thijs J. Beldman, Yohana C. Toner, Marnix A. Lameijer, Nils Rother, Siroon Bekkering, Abraham J. P. Teunissen, Xianxiao Zhou, Roy van der Meel, Joost Malkus, Sheqouia A. Nauta, Emma D. Klein, Francois Fay, Brenda L. Sanchez-Gaytan, Carlos Pérez-Medina, Ewelina Kluza, Yu-Xiang Ye, Gregory Wojtkiewicz, Edward A. Fisher, Filip K. Swirski, Matthias Nahrendorf, Bin Zhang, Yang Li, Bowen Zhang, Leo A. B. Joosten, Gerard Pasterkamp, Arjan Boltjes, Zahi A. Fayad, Esther Lutgens, Mihai G. Netea, Niels P. Riksen, Willem J. M. Mulder, Raphaël Duivenvoorden

Published: 2021-03-10

DOI: 10.1126/scitranslmed.abe1433

Source: Full article


Abstract

Prosaposin mediates inflammation in experimental and human atherosclerosis and is associated with cellular metabolism and mTOR signaling.