ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication

Authors: Dejie Wang, Jian Ma, Maria Victoria Botuyan, Gaofeng Cui, Yuqian Yan, Donglin Ding, Yingke Zhou, Eugene W. Krueger, Jiang Pei, Xiaosheng Wu, Liguo Wang, Huadong Pei, Mark A. McNiven, Dingwei Ye, Georges Mer, Haojie Huang

Published: 2021-06-18

DOI: 10.1126/sciadv.abd9208

Source: Full article

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Abstract

SPOP mutation disables 53BP1 ubiquitination and exclusion from DNA double-strand break sites and causes genome instability.