Synthetic auxotrophy remains stable after continuous evolution and in coculture with mammalian cells

Authors: Aditya M. Kunjapur, Michael G. Napolitano, Eriona Hysolli, Karen Noguera, Evan M. Appleton, Max G. Schubert, Michaela A. Jones, Siddharth Iyer, Daniel J. Mandell, George M. Church

Published: 2021-07-02

DOI: 10.1126/sciadv.abf5851

Source: Full article

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Abstract

A synthetic auxotroph does not escape from biocontainment after evolution, demonstrating that life does not always find a way.