Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity

Authors: Zintis Inde, Ben A. Croker, Clarence Yapp, Gaurav N. Joshi, Johan Spetz, Cameron Fraser, Xingping Qin, Le Xu, Brian Deskin, Elisa Ghelfi, Gabrielle Webb, Aaron F. Carlin, Yanfang Peipei Zhu, Sandra L. Leibel, Aaron F. Garretson, Alex E. Clark, Jason M. Duran, Victor Pretorius, Laura E. Crotty-Alexander, Chendi Li, Jamie Casey Lee, Chhinder Sodhi, David J. Hackam, Xin Sun, Aaron N. Hata, Lester Kobzik, Jeffrey Miller, Jin-Ah Park, Douglas Brownfield, Hongpeng Jia, Kristopher A. Sarosiek

Published: 2021-08-18

DOI: 10.1126/sciadv.abf8609

Source: Full article


Abstract

Changes in lung ACE2 expression and apoptotic priming throughout life span may affect COVID severity.