ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment

Authors: Jiye Liu, Teru Hideshima, Lijie Xing, Su Wang, Wenrong Zhou, Mehmet K. Samur, Tomasz Sewastianik, Daisuke Ogiya, Gang An, Shaobing Gao, Li Yang, Tong Ji, Giada Bianchi, Kenneth Wen, Yu-Tzu Tai, Nikhil Munshi, Paul Richardson, Ruben Carrasco, Yong Cang, Kenneth C. Anderson

Published: 2021-06-04

DOI: 10.1126/sciadv.abg2697

Source: Full article


Abstract

Blocking of MEK-ERK pathway overcomes myeloma cells resistance to immunomodulatory drugs in the bone marrow microenvironment.