Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake

Authors: Miaoqing Hu, Fan Yang, Yawen Huang, Xin You, Desheng Liu, Shan Sun, Sen-Fang Sui

Published: 2021-07-16

DOI: 10.1126/sciadv.abg3188

Source: Full article

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Abstract

Structures of NPC1L1 reveal how NPC1L1 senses the cholesterol level by conformational changes of the sterol-sensing domain.