Lactate and IL6 define separable paths of inflammatory metabolic adaptation

Authors: Stefanie Dichtl, Laura Lindenthal, Leonie Zeitler, Kristina Behnke, Daniela Schlösser, Birgit Strobl, Jürgen Scheller, Karim C. El Kasmi, Peter J. Murray

Published: 2021-06-23

DOI: 10.1126/sciadv.abg3505

Source: Full article

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Abstract

Inflammation induces macrophage histone lactylation uncoupled from arginine metabolism or M2 polarization.