TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Authors: Carolina Alquezar, Kathleen M. Schoch, Ethan G. Geier, Eliana Marisa Ramos, Aurora Scrivo, Kathy H. Li, Andrea R. Argouarch, Elisabeth E. Mlynarski, Beth Dombroski, Michael DeTure, Dennis W. Dickson, Jennifer S. Yokoyama, Ana M. Cuervo, Alma L. Burlingame, Gerard D. Schellenberg, Timothy M. Miller, Bruce L. Miller, Aimee W. Kao

Published: 2021-11-05

DOI: 10.1126/sciadv.abg3897

Source: Full article

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Abstract

TSC1/hamartin haploinsufficiency increases risk for tauopathy by promoting tau acetylation and accumulation.