Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension

Authors: Vinny Negi, Jimin Yang, Gil Speyer, Andres Pulgarin, Adam Handen, Jingsi Zhao, Yi Yin Tai, Ying Tang, Miranda K. Culley, Qiujun Yu, Patricia Forsythe, Anastasia Gorelova, Annie M. Watson, Yassmin Al Aaraj, Taijyu Satoh, Maryam Sharifi-Sanjani, Arun Rajaratnam, John Sembrat, Steeve Provencher, Xianglin Yin, Sara O. Vargas, Mauricio Rojas, Sébastien Bonnet, Stephanie Torrino, Bridget K. Wagner, Stuart L. Schreiber, Mingji Dai, Thomas Bertero, Imad Al Ghouleh, Seungchan Kim, Stephen Y. Chan

Published: 2021-10-21

DOI: 10.1126/sciadv.abh3794

Source: Full article


Abstract

A network dependency platform was generated to define a landscape of cancer drug mechanisms in pulmonary hypertension.