Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence

Authors: David Bakhshinyan, Ashley A. Adile, Jeff Liu, William D. Gwynne, Yujin Suk, Stefan Custers, Ian Burns, Mohini Singh, Nicole McFarlane, Minomi K. Subapanditha, Maleeha A. Qazi, Parvez Vora, Michelle M. Kameda-Smith, Neil Savage, Kim L. Desmond, Nazanin Tatari, Damian Tran, Mathieu Seyfrid, Kristin Hope, Nicholas A. Bock, Chitra Venugopal, Gary D. Bader, Sheila K. Singh

Published: 2021-12-08

DOI: 10.1126/sciadv.abi5568

Source: Full article

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Abstract

Gene expression profiling of medulloblastoma cells undergoing therapy identifies BPIFB4 as a novel target for recurrent disease.