Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

Authors: Sarika Heino, Shentong Fang, Marianne Lähde, Jenny Högström, Sina Nassiri, Andrew Campbell, Dustin Flanagan, Alexander Raven, Michael Hodder, Nadia Nasreddin, Hai-Hui Xue, Mauro Delorenzi, Simon Leedham, Tatiana V. Petrova, Owen Sansom, Kari Alitalo

Published: 2021-11-17

DOI: 10.1126/sciadv.abj0512

Source: Full article

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Abstract

Lef1 is induced in intestinal adenomas, in which it restricts ectopic crypt formation and tumor growth.