Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

Authors: Kevin Eislmayr, Annika Bestehorn, Luisa Morelli, Martina Borroni, Lieselotte Vande Walle, Mohamed Lamkanfi, Pavel Kovarik

Published: 2022-03-02

DOI: 10.1126/sciadv.abj7293

Source: Full article

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Abstract

Interleukin-1α (IL-1α) and IL-1β are inflammatory cytokines with important roles in health and disease. They trigger the same receptor and elicit comparable cellular responses but, for poorly understood reasons, are not redundant in vivo. Here, we decoupled IL-1α and IL-1β functions that drive protective responses against invasive infection with group A