Misexpression of genes lacking CpG islands drives degenerative changes during aging

Authors: Jun-Yeong Lee, Ian Davis, Elliot H. H. Youth, Jonghwan Kim, Gary Churchill, James Godwin, Ron Korstanje, Samuel Beck

Published: 2021-12-15

DOI: 10.1126/sciadv.abj9111

Source: Full article

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Abstract

Disrupted nuclear architecture triggers misexpression of genes lacking CpG islands and physiological deterioration during aging.