Four-dimensional nuclear speckle phase separation dynamics regulate proteostasis

Authors: William Dion, Heather Ballance, Jane Lee, Yinghong Pan, Saad Irfan, Casey Edwards, Michelle Sun, Jing Zhang, Xin Zhang, Silvia Liu, Bokai Zhu

Published: 2022-01-05

DOI: 10.1126/sciadv.abl4150

Source: Full article

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Abstract

A cell-autonomous 12-hour clock coordinates nuclear speckle LLPS with proteostasis control.