ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156

Authors: Balakrishna Koneru, Ahsan Farooqi, Thinh H. Nguyen, Wan Hsi Chen, Ashly Hindle, Cody Eslinger, Monish Ram Makena, Trevor A. Burrow, Joanne Wilson, Aaron Smith, Venkatesh Pilla Reddy, Elaine Cadogan, Stephen T. Durant, C. Patrick Reynolds

Published: 2021-08-18

DOI: 10.1126/scitranslmed.abd5750

Source: Full article

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Abstract

ATM activation at telomeres confers chemoresistance in ALT neuroblastoma and is reversible in preclinical models by ATM knockdown or inhibition.