Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue

Authors: Michael H. Radke, Victor Badillo-Lisakowski, Thiago Britto-Borges, Dieter A. Kubli, René Jüttner, Pragati Parakkat, Jacobo Lopez Carballo, Judith Hüttemeister, Martin Liss, Arne Hansen, Christoph Dieterich, Adam E. Mullick, Michael Gotthardt

Published: 2021-12-01

DOI: 10.1126/scitranslmed.abe8952

Source: Full article

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Abstract

RBM20-targeted antisense oligonucleotides improve cardiac function in mice with diastolic dysfunction and relaxation in human engineered heart tissue.