Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury

Authors: Neil S. N. Graham, Karl A. Zimmerman, Federico Moro, Amanda Heslegrave, Samia Abed Maillard, Adriano Bernini, John-Paul Miroz, Cornelius K. Donat, Maria Yanez Lopez, Niall Bourke, Amy E. Jolly, Emma-Jane Mallas, Eyal Soreq, Mark H. Wilson, Gavin Fatania, Dylan Roi, Maneesh C. Patel, Elena Garbero, Giovanni Nattino, Camelia Baciu, Enrico Fainardi, Arturo Chieregato, Primoz Gradisek, Sandra Magnoni, Mauro Oddo, Henrik Zetterberg, Guido Bertolini, David J. Sharp

Published: 2021-09-29

DOI: 10.1126/scitranslmed.abg9922

Source: Full article


Abstract

Axonal injury after TBI can be reliably quantified using plasma NfL, which predicts long-term functional outcomes and progressive neurodegeneration.