Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

Authors: Monique G. P. van der Wijst, Sara E. Vazquez, George C. Hartoularos, Paul Bastard, Tianna Grant, Raymund Bueno, David S. Lee, John R. Greenland, Yang Sun, Richard Perez, Anton Ogorodnikov, Alyssa Ward, Sabrina A. Mann, Kara L. Lynch, Cassandra Yun, Diane V. Havlir, Gabriel Chamie, Carina Marquez, Bryan Greenhouse, Michail S. Lionakis, Philip J. Norris, Larry J. Dumont, Kathleen Kelly, Peng Zhang, Qian Zhang, Adrian Gervais, Tom Le Voyer, Alexander Whatley, Yichen Si, Ashley Byrne, Alexis J. Combes, Arjun Arkal Rao, Yun S. Song, Gabriela K. Fragiadakis, Kirsten Kangelaris, Carolyn S. Calfee, David J. Erle, Carolyn Hendrickson, Matthew F. Krummel, Prescott G. Woodruff, Charles R. Langelier, Jean-Laurent Casanova, Joseph L. Derisi, Mark S. Anderson, Chun Jimmie Ye,

Published: 2021-08-24

DOI: 10.1126/scitranslmed.abh2624

Source: Full article


Abstract

Type I interferon autoantibodies in patients with COVID-19 are associated with poor interferon responses and increased LAIR1 abundance in leukocytes.