Toxicogenomics Data for Chemical Safety Assessment and Development of New Approach Methodologies: An Adverse Outcome Pathway‐Based Approach

Authors: Laura Aliisa Saarimäki, Jack Morikka, Alisa Pavel, Seela Korpilähde, Giusy del Giudice, Antonio Federico, Michele Fratello, Angela Serra, Dario Greco

Published: 2022-12-07

DOI: 10.1002/advs.202203984

Source: Full article

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Abstract

AbstractMechanistic toxicology provides a powerful approach to inform on the safety of chemicals and the development of safe‐by‐design compounds. Although toxicogenomics supports mechanistic evaluation of chemical exposures, its implementation into the regulatory framework is hindered by uncertainties in the analysis and interpretation of such data. The use of mechanistic evidence through the adverse outcome pathway (AOP) concept is promoted for the development of new approach