Wide-area transepithelial sampling with computer-assisted analysis to detect high grade dysplasia and cancer in Barrettʼs esophagus: a multicenter randomized study

Authors: Sanne N. van Munster, Philippe Leclercq, Rehan Haidry, Helmut Messmann, Andreas Probst, Krish Ragunath, Pradeep Bhandari, Alessandro Repici, Miguel Munoz-Navas, Stefan Seewald, Arnaud Lemmers, Glòria Fernández-Esparrach, Oliver Pech, Erik J. Schoon, Revital Kariv, Horst Neuhaus, Bas L. A. M. Weusten, Peter D. Siersema, Loredana Correale, Sybren L. Meijer, Gert de Hertogh, Jacques J.G.H.M. Bergman, Cesare Hassan, Raf Bisschops

Published: 2022-09-23

DOI: 10.1055/a-1949-9542

Source: Full article


Abstract

Background Current surveillance for Barrett’s esophagus (BE), consisting of four-quadrant random forceps biopsies (FBs), has an inherent risk of sampling error. Wide-area transepithelial sampling (WATS) may increase detection of high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). In this multicenter randomized trial, we aimed to evaluate WATS as a substitute for FB.