Advanced serrated polyps as a target of screening: detection rate and positive predictive value within a fecal immunochemical test-based colorectal cancer screening population

Authors: David E. F. W. M. van Toledo, Emilie C. H. Breekveldt, Joep E. G. IJspeert, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian Ramakers, Iris D. Nagtegaal, Monique E. van Leerdam, Manon C. W. Spaander, Iris Lansdorp-Vogelaar, Esther Toes-Zoutendijk, Evelien Dekker

Published: 2022-11-03

DOI: 10.1055/a-1971-3488

Source: Full article

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Abstract

Background Advanced serrated polyps (ASPs) have a comparable risk to advanced adenomas for progression to colorectal cancer (CRC). The yield of most CRC screening programs, however, is based on advanced adenomas and CRC only. We assessed the ASP detection rate, and positive predictive value (PPV) including ASPs in a fecal immunochemical test (FIT)-based screening program.