Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia

Authors: Rui Gong, Fangfang Jiang, Zane G. Moreland, Matthew J. Reynolds, Santiago Espinosa de los Reyes, Pinar Gurel, Arik Shams, James B. Heidings, Michael R. Bowl, Jonathan E. Bird, Gregory M. Alushin

Published: 2022-07-20

DOI: 10.1126/sciadv.abl4733

Source: Full article

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Abstract

The motor protein myosin-15 is necessary for the development and maintenance of mechanosensory stereocilia, and mutations in myosin-15 cause hereditary deafness. In addition to transporting actin regulatory machinery to stereocilia tips, myosin-15 directly nucleates actin filament (“F-actin”) assembly, which is disrupted by a progressive hearing loss mutation (p.D1647G, “