Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells

Authors: Yung-Hsuan Wu, Shu-Ting Mo, I-Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jinake Zhang, Ming-Zong Lai

Published: 2022-11-11

DOI: 10.1126/sciadv.abn9912

Source: Full article

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Abstract

Caspase-8 activity controls the switch from cell death to pyroptosis when apoptosis and necroptosis are blocked, yet how caspase-8 inactivation induces inflammasome assembly remains unclear. We show that caspase-8 inhibition via IETD treatment in Toll-like receptor (TLR)–primed