Authors: Neeraj Singh, Brati Das, John Zhou, Xiangyou Hu, Riqiang Yan
Published: 2022-07-20
Source: Full article
Abnormal accumulation of β-amyloid (Aβ) peptides is a culprit in Alzheimer’s disease (AD); blocking Aβ generation is therefore being explored as a logical approach for AD treatment. Here, we demonstrate that targeted inhibition of β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE-1) in microglia has unique advantages. When