Authors: Harvey G. Roweth, Michael W. Malloy, Gregory J. Goreczny, Isabelle C. Becker, Qiuchen Guo, Elizabeth A. Mittendorf, Joseph E. Italiano, Sandra S. McAllister, Elisabeth M. Battinelli
Published: 2022-10-12
Source: Full article
Despite abundant research demonstrating that platelets can promote tumor cell metastasis, whether primary tumors affect platelet-producing megakaryocytes remains understudied. In this study, we used a spontaneous murine model of breast cancer to show that tumor burden reduced megakaryocyte number and size and disrupted polyploidization. Single-cell RNA sequencing demonstrated that megakaryocytes from tumor-bearing mice exhibit a pro-inflammatory phenotype, epitomized by increased