Authors: Matthew J. Taylor, Adam M. Thompson, Sharif Alhajlah, Richard I. Tuxworth, Zubair Ahmed
Published: 2022-09-14
Source: Full article
DNA double-strand breaks occur in many acute and long-term neurological conditions, including neurodegeneration, neurotrauma, and stroke. Nonrepaired breaks chronically activate the DNA damage response in neurons, leading to neural dysfunction and apoptosis. Here, we show that targeting of the central ATM-Chk2 pathway regulating the response to double-strand breaks slows neural decline in