The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor–resistant ER

Authors: Isabel Soria-Bretones, Kelsie L. Thu, Jennifer Silvester, Jennifer Cruickshank, Samah El Ghamrasni, Wail Ba-alawi, Graham C. Fletcher, Reza Kiarash, Mitchell J. Elliott, Jordan J. Chalmers, Andrea C. Elia, Albert Cheng, April A. N. Rose, Mark R. Bray, Benjamin Haibe-Kains, Tak W. Mak, David W. Cescon

Published: 2022-09-07

DOI: 10.1126/sciadv.abq4293

Source: Full article

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Abstract

Inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i) are standard first-line treatments for metastatic ER