Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity

Authors: Amand F. Schmidt, Mimount Bourfiss, Abdulrahman Alasiri, Esther Puyol-Anton, Sandesh Chopade, Marion van Vugt, Sander W. van der Laan, Christian Gross, Chris Clarkson, Albert Henry, Tom R. Lumbers, Pim van der Harst, Nora Franceschini, Joshua C. Bis, Birgitta K. Velthuis, Anneline S. J. M. te Riele, Aroon D. Hingorani, Bram Ruijsink, Folkert W. Asselbergs, Jessica van Setten, Chris Finan

Published: 2023-04-26

DOI: 10.1126/sciadv.add4984

Source: Full article


Abstract

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging measurements of biventricular function and structure.