Authors: Wenqiang Chang, Ming Zhang, Xueyang Jin, Haijuan Zhang, Hongbo Zheng, Sha Zheng, Yanan Qiao, Haina Yu, Bin Sun, Xuben Hou, Hongxiang Lou
Published: 2022-12-16
Source: Full article
The global emergence of antifungal resistance threatens the limited arsenal of available treatments and emphasizes the urgent need for alternative antifungal agents. Targeting fungal pathogenic functions is an appealing alternative therapeutic strategy. Here, we show that cystathionine β-synthase (CBS), compared with cystathionine γ-lyase, is the major enzyme that synthesizes hydrogen sulfide in the pathogenic fungus