Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS

Authors: Isobel C. Mouat, Jessica R. Allanach, Naomi M. Fettig, Vina Fan, Anna M. Girard, Iryna Shanina, Lisa C. Osborne, Galina Vorobeychik, Marc S. Horwitz

Published: 2022-11-25

DOI: 10.1126/sciadv.ade6844

Source: Full article

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Abstract

While age-associated B cells (ABCs) are known to expand and persist following viral infection and during autoimmunity, their interactions are yet to be studied together in these contexts. Here, we directly compared CD11c