PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption

Authors: Sophia Ladraa, Lola Zerbib, Charles Bayard, Antoine Fraissenon, Quitterie Venot, Gabriel Morin, Alexandre P. Garneau, Pierre Isnard, Célia Chapelle, Clément Hoguin, Sylvie Fraitag, Jean-Paul Duong, Laurent Guibaud, Alix Besançon, Sophie Kaltenbach, Patrick Villarese, Vahid Asnafi, Christine Broissand, Nicolas Goudin, Michael Dussiot, Ivan Nemazanyy, Thomas Viel, Gwennhael Autret, Céline Cruciani-Guglielmacci, Jessica Denom, Julie Bruneau, Bertrand Tavitian, Christophe Legendre, Julien Dairou, Jean-Marc Lacorte, Pacifique Levy, Mario Pende, Michel Polak, Guillaume Canaud

Published: 2022-12-09

DOI: 10.1126/sciadv.ade7823

Source: Full article

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Abstract

PIK3CA