Authors: Ronghui Huang, Minyan Wang, Hong Deng, Jingkai Xu, Hong Yan, Yue Zhao, Zhuangzhi Shi
Published: 2023-01-13
Source: Full article
Enantioenriched phosphorus compounds play crucial roles in many fields ranging from catalyst to materials science to drug development. Despite advances in the construction of phosphacycles, incorporation of a P-chirogenic center into heterocycles remains challenging. Here, we report an effective method for the preparation of phosphacycles through nickel-catalyzed [4+2] heteroannulation of internal alkynes with aminophosphanes derived from