A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria

Authors: Sodiomon B. Sirima, Alphonse Ouédraogo, Alfred B. Tiono, Jean M. Kaboré, Edith C. Bougouma, Maurice S. Ouattara, Désiré Kargougou, Amidou Diarra, Noelie Henry, Issa N. Ouédraogo, Peter F. Billingsley, Anita Manoj, Yonas Abebe, Natasha KC, Adam Ruben, Thomas L. Richie, Eric R. James, Sudhaunshu Joshi, Biraj Shrestha, Kathy Strauss, Kirsten E. Lyke, Christopher V. Plowe, Gail E. Potter, Catherine Cox, Walter Jones, B. Kim Lee Sim, Stephen L. Hoffman, Matthew B. Laurens

Published: 2022-12-07

DOI: 10.1126/scitranslmed.abj3776

Source: Full article


Abstract

A highly effective malaria vaccine remains elusive despite decades of research.