APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression

Authors: Aylin Dincer, Charles D. Chen, Nicole S. McKay, Lauren N. Koenig, Austin McCullough, Shaney Flores, Sarah J. Keefe, Stephanie A. Schultz, Rebecca L. Feldman, Nelly Joseph-Mathurin, Russ C. Hornbeck, Carlos Cruchaga, Suzanne E. Schindler, David M. Holtzman, John C. Morris, Anne M. Fagan, Tammie L.S. Benzinger, Brian A. Gordon

Published: 2022-11-16

DOI: 10.1126/scitranslmed.abl7646

Source: Full article

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Abstract

The apolipoprotein E (