B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function?

Authors: Gregory M. Chen, Jan Joseph Melenhorst, Kai Tan

Published: 2022-06-22

DOI: 10.1126/scitranslmed.abn3353

Source: Full article

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Abstract

Chimeric antigen receptor (CAR) T cell therapies targeting CD19 and CD22 have been successful for treating B cell cancers, but CAR T cells targeting non–B cell cancers remain unsuccessful. We propose that rather than being strictly a side effect of therapy, the large number of CAR interactions with normal B cells may be a key contributor to clinical CAR T cell responses.