Authors: Amanda M. Pocratsky, Filipe Nascimento, M. Görkem Özyurt, Ian J. White, Roisin Sullivan, Benjamin J. O’Callaghan, Calvin C. Smith, Sunaina Surana, Marco Beato, Robert M. Brownstone
Published: 2023-05-03
DOI: 10.1126/scitranslmed.adg3904
Source: Full article
Dystonia, a neurological disorder defined by abnormal postures and disorganized movements, is considered to be a neural circuit disorder with dysfunction arising within and between multiple brain regions. Given that spinal neural circuits constitute the final pathway for motor control, we sought to determine their contribution to this movement disorder. Focusing on the most common inherited form of dystonia in humans, DYT1-