CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes

Authors: Taishi Onodera, Nicolas Sax, Takashi Sato, Yu Adachi, Ryutaro Kotaki, Takeshi Inoue, Ryo Shinnakasu, Takayuki Nakagawa, Shuetsu Fukushi, Tommy Terooatea, Mai Yoshikawa, Keisuke Tonouchi, Takaki Nagakura, Saya Moriyama, Takayuki Matsumura, Masanori Isogawa, Kazutaka Terahara, Tomohiro Takano, Lin Sun, Ayae Nishiyama, Shinnya Omoto, Masaharu Shinkai, Tomohiro Kurosaki, Kazuo Yamashita, Yoshimasa Takahashi

Published: 2023-06-14

DOI: 10.1126/sciadv.adf0661

Source: Full article


Abstract

Severe acute respiratory syndrome coronavirus 2–neutralizing antibodies primarily target the spike receptor binding domain (RBD). However, B cell antigen receptors (BCRs) on RBD-binding memory B (B