Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment

Authors: Xueliang Liu, Fan Li, Ziliang Dong, Chao Gu, Dongsheng Mao, Jingqi Chen, Lei Luo, Yuting Huang, Jie Xiao, Zhanchun Li, Zhuang Liu, Yu Yang

Published: 2023-08-02

DOI: 10.1126/sciadv.adf3329

Source: Full article


Abstract

Current clinical approaches to osteoporosis primarily target osteoclast biology, overlooking the synergistic role of bone cells, immune cells, cytokines, and inorganic components in creating an abnormal osteoporotic microenvironment. Here, metal-polyDNA nanoparticles (Ca-polyCpG MDNs) composed of Ca