TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells

Authors: Sierra M. Collins, Katherine A. Alexander, Stefan Lundh, Alexander J. Dimitri, Zhen Zhang, Charly R. Good, Joseph A. Fraietta, Shelley L. Berger

Published: 2023-07-19

DOI: 10.1126/sciadv.adh2605

Source: Full article

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Abstract

Chimeric antigen receptor (CAR) T cell therapy is used in treating human hematological malignancies, but its efficacy is limited by T cell exhaustion (T