Haplotype-phased genome unveils the butylphthalide biosynthesis and homoploid hybrid origin of

Authors: Bao Nie, Xueqing Chen, Zhuangwei Hou, Miaoxian Guo, Cheng Li, Wenkai Sun, Jiaojiao Ji, Lanlan Zang, Song Yang, Pengxiang Fan, Wenhao Zhang, Hang Li, Yuzhu Tan, Wei Li, Li Wang

Published: 2024-02-07

DOI: 10.1126/sciadv.adj6547

Source: Full article


Abstract

Butylphthalide is one of the first-line drugs for ischemic stroke therapy, while no biosynthetic enzyme for butylphthalide has been reported. Here, we present a haplotype-resolved genome of