Authors: Weimin Lin, Qiwen Li, Linfeng Liu, Qian Wang, Danting Zhang, Feiyu Wang, Ruoshi Xu, Yi Fan, Malcolm Xing, Chenchen Zhou, Quan Yuan
Published: 2024-05-17
Source: Full article
Trauma rapidly mobilizes the immune response of surrounding tissues and activates regeneration program. Manipulating immune response to promote tissue regeneration shows a broad application prospect. However, the understanding of bone healing dynamics at cellular level remains limited. Here, we characterize the landscape of immune cells after alveolar bone injury and reveal a pivotal role of infiltrating natural killer T (NKT) cells. We observe a rapid increase in NKT cells after injury, which inhibit osteogenic differentiation of mesenchymal stem cells (MSCs) and impair alveolar bone healing.